Tolerance of monocytes and macrophages in response to bacterial endotoxin
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چکیده
منابع مشابه
Passive Transfer of Tolerance to Pyrogenicity of Bacterial Endotoxin
The typical febrile response of normal rabbits given bacterial endotoxin intravenously may be modified by prior administration of plasma or, less effectively, serum of endotoxin-tolerant donors. This altered response is characterized by disappearance of the second rise in fever and by a striking reduction in fever index. It thus resembles the course of fever shown by rabbits made tolerant to en...
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The ability of bacterial endotoxins to produce local inflammation has been recognized as one of the many biologic activities of these intriguing products of the gram-negative bacterial cell.1" This property of endotoxin, however, has not been studied extensively with the highly purified materials now available. Preliminary observations are reported here on the inflammatory response elicited by ...
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Endotoxin tolerance is characterized by diminished expression of inflammatory cytokines after sequential exposure to Toll-like receptor stimuli. Many mechanisms contribute to tolerance; however, chromatin remodeling appears to be the most significant regulator. The type II interferon, IFN-γ, has been recognized as being able to reverse or abrogate the establishment of tolerance. Type I interfer...
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Tumor necrosis factor (TNF) tolerance in monocytes and macrophages means that preexposure to TNF reduces the sensitivity in these cells to a subsequent restimulation with this cytokine. Differential effects arise following preincubation with both low and high doses of TNF resulting in absolute as well as induction tolerance affecting specific immunologically relevant gene sets. In this review a...
متن کاملDissociation of endotoxin tolerance and differentiation of alternatively activated macrophages.
Endotoxin tolerance is a complex phenomenon characterized primarily by decreased production of proinflammatory cytokines, chemokines, and other inflammatory mediators, whereas the expression of other genes are induced or unchanged. Endotoxin tolerance is induced by prior exposure of murine macrophages/human monocytes, experimental animals, or people to TLR ligands. Although recent studies repor...
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ژورنال
عنوان ژورنال: Postępy Higieny i Medycyny Doświadczalnej
سال: 2017
ISSN: 0032-5449,1732-2693
DOI: 10.5604/01.3001.0010.3802